abstract：:The acute effects of proton whole-body irradiation on the distribution and function of leukocyte populations in the spleen and blood were examined and compared to the effects of photons derived from a (60)Co gamma-ray source. Adult female C57BL/6 mice were exposed to a single dose (3 Gy at 0.4 Gy/min) of protons at sp...

journal_title：Radiation research

authors： Kajioka EH,Andres ML,Li J,Mao XW,Moyers MF,Nelson GA,Slater JM,Gridley DS

更新日期：2000-05-01 00:00:00

abstract：:Human keratinocytes show a bystander effect when exposed to low doses of low-LET radiation. In this paper, data are presented showing a method of correcting the overall survival curve to enable analysis of the relative contributions of the bystander effect and the effect attributable to direct interaction of the radia...

journal_title：Radiation research

authors： Seymour CB,Mothersill C

更新日期：2000-05-01 00:00:00

abstract：:Human peripheral blood samples collected from three healthy human volunteers were exposed in vitro to pulsed-wave 2450 MHz radiofrequency (RF) radiation for 2 h. The RF radiation was generated with a net forward power of 21 W and transmitted from a standard gain rectangular antenna horn in a vertically downward direct...

journal_title：Radiation research

authors： Vijayalaxmi,Leal BZ,Szilagyi M,Prihoda TJ,Meltz ML

更新日期：2000-04-01 00:00:00

abstract：:This study was designed to determine whether patients taking angiotensin-converting enzyme (ACE) inhibitors while receiving radiation therapy for lung cancer are protected from developing symptomatic radiation pneumonitis. The records of 213 eligible patients receiving thoracic irradiation for lung cancer with curativ...

journal_title：Radiation research

authors： Wang LW,Fu XL,Clough R,Sibley G,Fan M,Bentel GC,Marks LB,Anscher MS

更新日期：2000-04-01 00:00:00

abstract：:Chomentowski, M., Kellerer, A. M. and Pierce, D. A. Radiation Dose Dependences in the Atomic Bomb Survivor Cancer Mortality Data: A Model-Free Visualization. The standard approach to obtaining nominal risk coefficients for radiation-related cancer involves fitting linear or linear-quadratic dose-response functions. Th...

journal_title：Radiation research

authors： Chomentowski M,Kellerer AM,Pierce DA

更新日期：2000-03-01 00:00:00

abstract：:Peroxidation of unconjugated polyunsaturated fatty acids such as linolenic acid proceeds through a free radical chain mechanism and is accompanied by the formation of conjugated dienes such as hydroperoxides. In an investigation of radiation-induced oxidation of aqueous linolenate, we have measured two indexes of pero...

journal_title：Radiation research

authors： Hindo J,Hauville C,Rémita S,Thérond P,Couturier M,Jore D,Gardès-Albert M

更新日期：2000-02-01 00:00:00

abstract：:Numerous experimental and clinical studies have been completed regarding the effects of carbogen and nicotinamide on tumor oxygenation and radiosensitivity. The current study incorporates three physiological measurement techniques to further define spatial variations in oxygen availability and development of hypoxia a...

journal_title：Radiation research

authors： Fenton BM,Lord EM,Paoni SF

更新日期：2000-01-01 00:00:00

abstract：:These studies were carried out to examine the capacity of alpha-difluoromethylornithine (DFMO) to modulate cell proliferation and apoptosis in cells of squamous cell carcinomas (SCCs) of the head and neck. Exposure of cells to DFMO (5 mM for 48 h) depleted intracellular putrescine and spermidine levels (greater than 5...

journal_title：Radiation research

authors： Bock JM,Pickart MA,Pink JJ,Harari PM

更新日期：1999-12-01 00:00:00

abstract：:To evaluate the function of the reticuloendothelial system and macrophage-monocyte system, blood samples from Thorotrast patients and age-matched healthy controls were used to determine the titer of plasma antibodies to lipid A and the numbers of several lymphocyte subclasses in peripheral blood and for an autoradiogr...

journal_title：Radiation research

authors： Abe H,Kawahara T,Gondou K,Sakisaka S,Sata M

更新日期：1999-12-01 00:00:00

abstract：:The German Thorotrast study comprises 2,326 patients and 1,890 controls. Forty-eight Thorotrast patients and 239 controls are still alive and are invited for a follow-up examination every 2 years. In the deceased patients, the following neoplastic diseases with excess rates were registered (Thorotrast/controls): liver...

journal_title：Radiation research

authors： van Kaick G,Dalheimer A,Hornik S,Kaul A,Liebermann D,Lührs H,Spiethoff A,Wegener K,Wesch H

更新日期：1999-12-01 00:00:00

abstract：:This report compares the deterministic effects from an alpha-particle-emitting radionuclide, (239)PuO(2), and a beta-particle emitter, (144)Ce in fused aluminosilicate particles (FAP). The studies were conducted in beagle dogs of both genders exposed by inhalation to aerosols of the radionuclides. The initial lung bur...

journal_title：Radiation research

authors： Muggenburg BA,Hahn FF,Ménache MG,Guilmette RA,Boecker BB

更新日期：1999-12-01 00:00:00

abstract：:To elucidate the nature and kinetics of DNA strand breaks caused by low-energy Auger electron emitters, we compared the yields of DNA breaks in supercoiled pUC19 DNA in the presence of the (.)OH scavenger dimethyl sulfoxide (DMSO) after the decay of (125)I (1) in proximity to DNA after minor-groove binding ((125)I-iod...

journal_title：Radiation research

authors： Kassis AI,Harapanhalli RS,Adelstein SJ

更新日期：1999-11-01 00:00:00

abstract：:The photodynamic properties of a second-generation photodynamic sensitizer, meta-tetra(hydroxyphenyl)chlorin (mTHPC) were studied by dye-sensitized photoinactivation (650 nm) of HT29 human adenocarcinoma cells in culture. The photocytotoxicity of mTHPC in vitro depended on the presence of molecular oxygen. A strong in...

journal_title：Radiation research

authors： Melnikova VO,Bezdetnaya LN,Potapenko AY,Guillemin F

更新日期：1999-10-01 00:00:00

abstract：:We have tested an 836.55 MHz field with North American Digital Cellular (NADC) modulation in a 2-year animal bioassay that included fetal exposure. In offspring of pregnant Fischer 344 rats, we tested both spontaneous tumorigenicity and the incidence of induced central nervous system (CNS) tumors after a single dose o...

journal_title：Radiation research

authors： Adey WR,Byus CV,Cain CD,Higgins RJ,Jones RA,Kean CJ,Kuster N,MacMurray A,Stagg RB,Zimmerman G,Phillips JL,Haggren W

更新日期：1999-09-01 00:00:00

abstract：:Radiation-induced free radical damage in solid-state DNA arises from direct-type damage mechanisms. In the present study, free radical yields in film and lyophilized Na DNA model systems are compared. The free radical yields in lyophilized samples are significantly greater than those in films. Since DNA conformation c...

journal_title：Radiation research

authors： Milano MT,Bernhard WA

更新日期：1999-08-01 00:00:00

abstract：:We previously reported that a priming dose of 0.3 Gy on gestation day 11 significantly increased the rate of living fetuses and reduced the incidence of congenital malformations caused by exposure to 5 Gy X rays on gestation day 12 in ICR mice. In the present study, postnatal development of the live offspring was inve...

journal_title：Radiation research

authors： Wang B,Ohyama H,Haginoya K,Odaka T,Itsukaichi H,Nose M,Nakajima T,Yukawa O,Yamada T,Hayata I

更新日期：1999-08-01 00:00:00

abstract：:Previous studies showed that a 6-week pretreatment of rats with testosterone plus estradiol enhanced the recovery of spermatogenesis 9 weeks after gamma irradiation, resulting in a dose-modifying factor (DMF) of about 2. To test whether the effect of the hormone treatment was mediated through changes in oxygen tension...

journal_title：Radiation research

authors： Wilson G,Kangasniemi M,Meistrich ML

更新日期：1999-07-01 00:00:00

abstract：:Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) is one of the important responses of cells to an external stress such as ionizing radiation. We studied radiation-induced NF-kappaB activation in vivo in male BALB/c mice. After the mice were exposed to 8.5 Gy total-body gamma irradiation, the sp...

journal_title：Radiation research

authors： Zhou D,Brown SA,Yu T,Chen G,Barve S,Kang BC,Thompson JS

更新日期：1999-06-01 00:00:00

abstract：:To approach treatment of micrometastases of steroid receptor-rich cancers using estrogen receptor-directed therapy with Auger electrons, multicellular spheroids of the estrogen receptor-rich human breast cancer cell line, MCF-7, were prepared and exposed to a range of concentrations of an Auger electron-emitting estro...

journal_title：Radiation research

authors： Kearney T,Hughes A,Hanson RN,DeSombre ER

更新日期：1999-05-01 00:00:00

abstract：:Impaired fluid and electrolyte transport in the intestine is a well-recognized characteristic of radiation-induced pathologies in the gastrointestinal tract. The aim of this study was to investigate the responsiveness of the epithelium of the colon of the rat to electrical and pharmacological (serotonin, carbachol) st...

journal_title：Radiation research

authors： François A,Dublineau I,Lebrun F,Ksas B,Griffiths NM

更新日期：1999-04-01 00:00:00

abstract：:The purpose of this study was to determine the antimutagenicity of WR-1065 added after irradiation of cells of cell lines differing in their ability to rejoin radiation-induced DNA double-strand breaks (DSBs). The postirradiation antimutagenicity of WR-1065 at the thymidine kinase locus was demonstrated for L5178Y (LY...

journal_title：Radiation research

authors： Evans HH,Horng MF,Ricanati M,McCoy EC

更新日期：1999-04-01 00:00:00

abstract：:Single crystals of guanine hydrochloride monohydrate, guanine hydrochloride dihydrate and anhydrous guanine dihydrochloride, doped with thioguanine, were irradiated with X and gamma rays. In all three systems the dominant radicals were associated with thioguanine. In the former two systems the stabilized species is th...

journal_title：Radiation research

authors： Herak JN,Sanković K,Krilov D,Hüttermann J

更新日期：1999-03-01 00:00:00

abstract：:Reverse-biased silicon p-n junction arrays using Silicon-On-Insulator technology have been proposed as microdosimeters. The performance of such detectors in boron neutron capture therapy (BNCT) is discussed. This work provides the first reported measurements using boron-coated silicon diode arrays as microdosimeters i...

journal_title：Radiation research

authors： Bradley PD,Rosenfeld AB,Allen B,Coderre J,Capala J

更新日期：1999-03-01 00:00:00

abstract：:Wortmannin has been shown to be an efficient radiosensitizer. Since wortmannin is able to inhibit DNA-dependent protein kinase (DNA-PK) and double-strand break (DSB) rejoining, it is believed that its mechanism of radiation sensitization is through the inhibition of DNA-PK-mediated repair of DSBs. However, since wortm...

journal_title：Radiation research

authors： Chernikova SB,Wells RL,Elkind MM

更新日期：1999-02-01 00:00:00

abstract：:We have developed a new detection method for measuring distributions of energy depositions from particles characterized by low linear energy transfers (LETs). In particular, we have developed a detection system to measure energy depositions produced by electrons and photons on nanometer scales. The detector is based u...

journal_title：Radiation research

authors： Evans TM,Wang CK

更新日期：1999-01-01 00:00:00

abstract：:The linear no-threshold extrapolation from a dose-response relationship for ionizing radiation derived at higher doses to doses for which regulatory standards are proposed is being challenged by some scientists and defended by others. It appears that the risks associated with exposures to doses of interest are below t...

journal_title：Radiation research

authors： Fry RJ,Grosovsky A,Hanawalt PC,Jostes RF,Little JB,Morgan WF,Oleinick NL,Ullrich RL

更新日期：1998-12-01 00:00:00

abstract：:Using atomic force microscopy (AFM), we have investigated neutron-induced DNA double-strand breaks in plasmids in aqueous solution. AFM permits direct measurement of individual DNA molecules with an accuracy of a few nanometers. Furthermore, the analysis of the DNA fragment size distribution is non-parametric, whereas...

journal_title：Radiation research

authors： Pang D,Berman BL,Chasovskikh S,Rodgers JE,Dritschilo A

更新日期：1998-12-01 00:00:00

abstract：:Three-dimensional treatment planning systems used extensively for external-beam treatments have recently been applied for use in brachytherapy. Localization of structures in 3D from imaging studies integrated into computerized systems for planning of implants and evaluation allows 3D dose distributions to be indexed t...

journal_title：Radiation research

authors： Martel MK,Narayana V

更新日期：1998-11-01 00:00:00

abstract：:A significant fraction of DNA damage produced by ionizing radiation comes from free radicals generated during the radiolysis of water, that is, by indirect effects. The hydroxyl radical, the principal damaging species, produces single-strand breaks and a plethora of base and sugar lesions that can be cytotoxic or muta...

journal_title：Radiation research

authors： Wallace SS

更新日期：1998-11-01 00:00:00

abstract：:Cells from an infinite-life-span near-diploid human fibroblast cell strain, MSU-1.1, were transformed after a single exposure to 60Co gamma radiation. The frequency of transformation as measured by the number of induced foci per 10(6) cells was a linear function of dose. Cells from 13 independent foci from gamma-irrad...

journal_title：Radiation research

authors： O'Reilly S,Walicka M,Kohler SK,Dunstan R,Maher VM,McCormick JJ

更新日期：1998-11-01 00:00:00

abstract：:We demonstrate by western analysis that the expression levels of TP53 (formerly known as p53), CDKN1A (formerly known as p21Waf1), CDC2 (formerly known as p34cdc2), CCNB1 (cyclin B1) and RAD51 are significantly modulated in confluent, density-inhibited human diploid cell populations exposed to doses where only a small...

journal_title：Radiation research

authors： Azzam EI,de Toledo SM,Gooding T,Little JB

更新日期：1998-11-01 00:00:00

abstract：:The effect of age at exposure on induction of mammary carcinoma was studied in female rats of the inbred WAG/Rij strain that were treated with estrogen. Groups of 40 animals were exposed to a single total-body dose of 1 or 2 Gy of 137Cs gamma radiation at age 8, 10, 12, 15, 22, 36 or 64 weeks. Hormone levels in the an...

journal_title：Radiation research

authors： Bartstra RW,Bentvelzen PA,Zoetelief J,Mulder AH,Broerse JJ,van Bekkum DW

更新日期：1998-10-01 00:00:00

abstract：:We investigated delayed reproductive death and chromosome bridge formation in mitotic cells in colonies of normal human embryonic cells which survived exposure to 6 Gy of X rays. Eighteen primary clones each derived from control and irradiated cultures were isolated and secondary colonies were grown up. Six of the pri...

journal_title：Radiation research

authors： Suzuki K,Takahara R,Kodama S,Watanabe M

更新日期：1998-10-01 00:00:00

abstract：:The late effects of heavy-ion irradiation on the spinal cord of the rat were investigated histologically and morphometrically. After a single exposure of each animal's lower thoracic and lumbar spinal cord to a carbon-ion beam, the animals were observed clinically for up to 69 weeks and their spinal cords were examine...

journal_title：Radiation research

authors： Okada S,Okeda R,Matsushita S,Kawano A

更新日期：1998-09-01 00:00:00

abstract：:The concentrations of uranium isotopes and their decay products 226Ra, 222Rn, 210Pb and 210po have been analyzed in the mineral spring waters of a highly radioactive region of Brazil: Aguas da Prata. This region is located in the Poços de Caldas Plateau, one of the largest weathered alkaline intrusions in the world. D...

journal_title：Radiation research

authors： Mazzilli B,Camargo IM,Oliveira J,Nieri A,Sampa MH,Silva BL

更新日期：1998-08-01 00:00:00

abstract：:Single crystals of disodium beta-glycerophosphate pentahemihydrate (betaGP), Na2x(HO)CH2CH(PO(4)2-)CH2(OH)x5 1/2H2O, were X-irradiated at 77 and 280 K. EPR, ENDOR and FSE techniques were used to study the formation of free radicals in these irradiated crystals to characterize possible reaction mechanisms leading to de...

journal_title：Radiation research

authors： Baine TJ,Sagstuen E

更新日期：1998-08-01 00:00:00

abstract：:In a recent study (Int. J. Radiat. Oncol. Biol. Phys. 36, 635-639, 1996), 1H nuclear magnetic resonance (NMR) spectroscopy was used to demonstrate significant decreases in lactate levels after gamma irradiation of radiosensitive RIF-1 tumors in vitro. For comparison, we have examined the effects of gamma radiation on ...

journal_title：Radiation research

authors： Aboagye EO,Bhujwalla ZM,He Q,Glickson JD

更新日期：1998-07-01 00:00:00

abstract：:As a follow-up to the two previous surveys of radiation therapy among the atomic bomb survivors, a large-scale survey was performed to document (1) the number of radiation therapy treatments received by the atomic bomb survivors and (2) the types of radiation treatments conducted in Hiroshima and Nagasaki. The previou...

journal_title：Radiation research

authors： Kato K,Antoku S,Russell WJ,Fujita S,Pinkston JA,Hayabuchi N,Hoshi M,Kodama K

更新日期：1998-06-01 00:00:00

abstract：:Mortality data for B6CF1 mice exposed to 60Co gamma rays for the duration of life were used to make quantitative predictions of age-specific mortality observed in comparably exposed beagles. Simple Kaplan-Meier survival curves for the beagles and their 95% confidence intervals were computed for each dose-rate group ob...

journal_title：Radiation research

authors： Carnes BA,Olshansky SJ,Grahn D

更新日期：1998-05-01 00:00:00

abstract：:The statistical distribution of the number of ion pairs per ionizing event in a small volume simulating a tissue sphere was obtained by applying the Expectation-Maximization (EM) algorithm to experimental spectra measured by exposing a Rossi-type spherical proportional counter to gamma radiation. The normalized experi...

journal_title：Radiation research

authors： Obelić B,Srdoc D,Djurić PM,Marino SA

更新日期：1998-05-01 00:00:00